Jinan Meigao Biopharmaceutical Technology Co., Ltd.
Obeticholic acid increases the expression of FXR-regulated genes in rat hepatocytes Obeticholic acidreduces expression of liver JNK-1 and JNK-2 . Obeticholic acid (256 μg/mL) shows complete inhibition of bacterial growth in all strains tested. Intestinal permeability remains unaffected after Obeticholic acid-addition to an IFN-γ-exposed intestinal epithelium of Caco-2 cells
In Vivo Obeticholic acid (10 mg/kg/day) completely reverted cholestasis induced by E217α. Administration of 6-ECDCA partially prevents the impairment in total bile acid output caused by E217α by increasing the relative abundance of β-MCA and TCDCA and TDCA. INT-747 (10 mg/kg) and HS increases the pulmonary congestion in the animals.INT-747 does not improve renal pathology in the HS-fed animals. INT-747 (5 mg/kg) significantly increases survival in BDL rats. INT-747-treated BDL rats exhibits a significant selective ileal increase in expression of pore-closing claudin-1. Ileal expression of ZO-1 is significantly up-regulated in INT-747-treated BDL rats.
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