large scale WY-14643 in stock

Pirnixicacid ,WY-14643 ,Cas#50892-23-4

Jinan Meigao Biopharmatech can supply high quality ,WY-14643 ,Cas#50892-23-4 with low price, ,WY-14643 ,Cas#50892-23-4 in stokc 100KG regularly

Wy-14,643 (Pirinixic acid) is a moderate agonist of PPARα and PPARγ with IC50 of 36.5 μM and 53.7 μM, respectively. IC50 value: 36.5 μM (for PPARα), 53.7 μM (for PPARγ) Target: PPARα, PPARγ in vitro: Wy-14,643 is a moderate agonist of PPARα and PPARγ, leads to low micromolar active balanced dual agonists of PPARα and PPARγ. The aliphatic substitution in α-position of the carboxylic acid head group of Wy-14,643 leads to more potent dual PPARα/γ agonists with a significant preference towards PPARα. Wy-14,643 exhibits beneficial effects in various inflammation-related processes in a slow, long-termed fashion. in vivo: Wy-14,643 shows beneficial effects in animal models of inflammation and cardiovascular diseases that rely on slow-acting transcriptional events modulating protein expression. Wy-14,643 reduces the expression and production of cytokines, adhesion molecules, inducible NO synthase, heme oxygenase-1, and cyclooxygenase-2. Wy-14,643 inhibits human aldose reductase activity and increased uncoupling of oxidative phosphorylation in isolated mitochondria.

Jinan Meigao Biopharmatech. , located in Jinan New Material Industrial Park, focus on the customer manufacture of multiple functional chemicals and advanced intermediates for pharmaceutical, agricultural and biopharmaceutical industry. The company has state of art manufacture plants, GMP like and hydrogenation pilot plants. We manufacture over 100 advanced intermediates and chemicals, ranging from muti kilograms to multi tons annually

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